GRADE POINTS FOR CLINICAL GUIDELINE PANELISTS #4 - FIRST SUMMARY

GRADE points are intended to be brief summaries of the major concepts of rating evidence using the GRADE approach.

To summarize last week's blog series, here's your first list of what you've learned so far.

  1. GRADE summarizes the evidence by outcome across all the relevant studies.
  2. GRADE rates confidence in the body of evidence for each outcome as High, Moderate, Low or Very Low
  3. Confidence in the body of evidence can vary for each outcome, even when derived from the same set of studies.
  4. GRADE uses 5 domains to rate confidence in the evidence derived from randomized controlled trials.
  5. The 5 domains used to rate confidence in the evidence derived from RCT studies are independent and given equal weight.
  6. Each domain can be downgraded by one or two levels.
  7. GRADE starts evidence derived from randomized controlled trials at High and rates down for deficiencies in any of the domains.
  8. Downgrading by 3 levels results in a Very Low rating, which is the lowest rating no matter how many reasons for downgrading exist.
  9. Study quality, or risk of bias, is only one of the 5 domains. As such, it only accounts for 20% of the overall GRADE.

More GRADE points in future blogs. 

And you can always read ahead and get more detail in the GRADE HANDBOOK

TheEvidenceDoc November 13, 2017